With Donald Trump returning to the White House, this snap analysis offers an early look at how his presidency could reshape U.S. relations with key Latin American countries. Focusing on Mexico, Venezuela, and Brazil, and Argentina, we outline initial perspectives on the potential for renewed trade tensions, migration policy shifts, sanctions on Venezuela, and diplomatic dynamics with regional governments. Designed as a timely, high-level briefing, this piece provides stakeholders with quick but extremely relevant insights into the potential impacts on the region in the weeks and months ahead.